Xuduudda Tiknoolajiyadda Glutaraldehyde: Horumarka Tiknoolajiyadda Ka-hortagga Kalsiyaynta

Dhinaca qalabka wadnaha iyo xididdada dhiigga, glutaraldehyde waxaa muddo dheer loo isticmaali jiray in lagu daaweeyo unugyada xayawaanka (sida pericardium lo'da) si loo soo saaro waalka bioprosthetic. Si kastaba ha ahaatee, kooxaha aldehyde ee ka baxsan hababka dhaqameed waxay keeni karaan kalsiyum ka dib beerista, taasoo wiiqaysa cimriga dheer ee alaabta.

Iyadoo wax laga qabanayo caqabaddan, daraasaddii ugu dambeysay ee la daabacay Abriil 2025 ayaa soo bandhigtay xal cusub oo ka hortagga kalsiyum-ka (magaca badeecada: Periborn), taasoo gaartay horumar la taaban karo.

1. Casriyeynta Tiknoolajiyadda Aasaasiga ah:

Xalkani wuxuu soo bandhigayaa dhowr horumarin oo muhiim ah oo lagu sameeyay habka isku xidhka glutaraldehyde ee dhaqameed:

Isku-xirka Dabiiciga ah ee dareeraha ah:
Isku xidhka Glutaraldehyde waxaa lagu sameeyaa dareere dabiici ah oo ka kooban 75% ethanol + 5% octanol. Habkani wuxuu si wax ku ool ah uga caawiyaa in si wax ku ool ah looga saaro phospholipids-ka unugyada inta lagu jiro isku xidhka - phospholipids-ku waa goobaha ugu muhiimsan ee lagu sameeyo kalsiyum.

Wakiilka Buuxinta Booska:

Ka dib marka la isku xidho, polyethylene glycol (PEG) waxaa loo isticmaalaa sidii wakiil buuxinaya booska, kaas oo dhex gala meelaha u dhexeeya fiilooyinka kolajka. Tani waxay labadaba ka ilaalisaa goobaha nucleation-ka ee kiristaallada hydroxyapatite waxayna ka hortagtaa in kalsiyum iyo fosfolipids ay ka soo galaan balaasmaha martida loo yahay.

Shaabadeynta Terminalka:

Ugu dambeyntii, daawaynta glycine waxay dhexdhexaadisaa kooxaha aldehyde ee aan firfircoonayn ee haray, taasoo meesha ka saaraysa arrin kale oo muhiim ah oo kicisa kalsiyum iyo sunta sunta.

2. Natiijooyinka Caafimaad ee Cajiibka ah:

Tiknoolajiyaddan waxaa loo adeegsaday qaab-dhismeedka wadnaha ee lo'da oo lagu magacaabo "Periborn." Daraasad dabagal caafimaad oo daboolaysa 352 bukaan oo muddo 9 sano ah ka badan ayaa muujisay xorriyad ka timid dib-u-qalliin sababtoo ah arrimo la xiriira badeecada oo gaaraya 95.4%, taasoo xaqiijinaysa waxtarka istaraatiijiyaddan cusub ee ka hortagga kalsiyum-ka iyo cimri dhererkeeda muddada dheer ee gaarka ah.

Muhiimadda Horumarkan:

Ma aha oo kaliya inay wax ka qabanayso caqabad muddo dheer soo jirtay oo ku saabsan baallooyinka bayoprosthetic-ga, iyadoo kordhinaysa cimriga wax soo saarka, laakiin sidoo kale waxay ku duraysaa firfircooni cusub codsiga glutaraldehyde ee agabka bayoolojiga ee heerka sare ah.