Xudduudda Tignoolajiyada Glutaraldehyde: Horumarka Tignoolajiyada Ka-hortagga Calcifiga

Dhinaca beeridda xididdada wadnaha, glutaraldehyde ayaa muddo dheer loo isticmaalay in lagu daweeyo unugyada xayawaanka (sida bovine pericardium) si loo soo saaro valves bioprosthetic. Si kastaba ha noqotee, kooxaha aldehyde ee bilaashka ah ee ka soo jeeda hababka dhaqameed waxay u horseedi karaan caleenta tallaalka ka dib, taas oo wax u dhimaysa cimriga muddada dheer ee alaabta.

Wax ka qabashada caqabadan, daraasaddii ugu dambeysay ee la daabacay Abriil 2025 waxay soo bandhigtay xal cusub oo ka hortagga calcification xal (magaca badeecada: Periborn), oo lagu gaaray horumar la taaban karo.

1. Kobcinta Farsamada Xudunta ah:

Xalkani wuxuu soo bandhigayaa dhowr horumar oo muhiim ah oo ku saabsan habka isku xirka glutaraldehyde ee dhaqameed:

Isku-xidhka Isku-xidhka Solvent Organic:
Isku-xidhka Glutaraldehyde waxaa lagu sameeyaa dareere organic ah oo ka kooban 75% ethanol + 5% octanol. Habkani wuxuu kaa caawinayaa in si wax ku ool ah meesha looga saaro fosfoolipids unug inta lagu jiro isku-xirnaanta-fosfoolipids oo ah goobaha asaasiga ah ee nucleation-ka ee calcification.

Wakiilka boos-buuxinta:

Isku-xidhka ka dib, polyetylen glycol (PEG) ayaa loo isticmaalaa sidii wakiil meel buuxin ah, oo dhexgalinaysa farqiga u dhexeeya fiilooyinka kolajka. Labadani waxay difaacayaan goobaha nucleation-ka ee kiristaalo hydroxyapatite waxayna ka hortagayaan galitaanka kaalshiyamka iyo fosfoolipids ee balasmaha martida loo yahay.

Xiritaanka Terminalka:

Ugu dambeyntii, daawaynta glycine waxay ka takhalustaa haraaga, kooxaha aldehyde ee xorta ah, taas oo meesha ka saaraysa arrin kale oo muhiim ah oo kiciya calcification iyo cytotoxicity.

2.Natiijooyinka Caafimaad ee aadka u wanaagsan:

Tignoolajiyadan ayaa lagu dabaqay xuubka xuubka wadnaha ee lo'da ee loo yaqaan "Periborn." Daraasad dabagal ah oo caafimaad oo daboolaysa 352 bukaan oo ka badan 9 sano ayaa muujisay xorriyadda dib-u-shaqaynta sababtoo ah arrimaha la xidhiidha wax soo saarka oo sarreeya 95.4%, taas oo xaqiijinaysa waxtarka istiraatiijiyaddan cusub ee ka hortagga calcification iyo adkeysigeeda muddada dheer ee gaarka ah.

Muhiimadda Horumarkan:

Ma aha oo kaliya in ay wax ka qabato caqabadda muddada dheer soo jirtay ee beeraleyda bioprosthetic valves, kordhinta cimriga alaabta, laakiin sidoo kale waxay ku duraysaa firfircooni cusub codsiga glutaraldehyde ee qalabka-dhamaadka sare ee bayomedical.